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Table 1. Sustained-release Steroid Options^19-23

	Indication	Delivery	Duration/ Efficacy	Contraindications	Complications	Adverse Events
Fluocinolone Acetonide
Yutiq (0.18 mg, EyePoint Pharmaceuticals)	Non-infectious posterior uveitis	Intravitreal, non-bioerodible	Up to 36 months	Active ocular infection, avoid in aphakia	Post-injection endophthalmitis	56% of patients developed a cataract within 1 year; 43% were on at least one IOP-lowering medication; 2% required glaucoma surgery
Retisert (0.59 mg, Bausch + Lomb)	Chronic non-infectious posterior uveitis, patients who cannot tolerate systemic therapy	Surgically implanted and sutured at pars plana	Up to 30 months	Active ocular infection, consider systemic therapy if patients also have systemic disease and bilateral ocular disease	Surgical complications of hypotony and vitreous hemorrhage; post-operative complications of wound site erythema, dehiscence, hypotony (9.4%), and scleral thinning over implant	Within 3 years, 77% of patients require IOP drops, 37% require filtering procedures, and nearly all phakic eyes require cataract surgery
Dexamethasone
Ozurdex (0.7 mg, Allergan)	Diabetic macular edema, retinal vein occlusion-associated macular edema, non-infectious posterior uveitis	Intravitreal, bioerodible	3 to 4 months	Active ocular infection, advanced glaucoma, or when posterior lens capsule is not intact (risk of anterior chamber migration)	Post-injection endophthalmitis and hypotony (from wound leak)	High incidence of cataract development compared to sham; IOP rise typically 4 to 6 weeks following injection
Triamcinolone Acetonide
Xipere (4 mg/0.1 mL, Bausch + Lomb)	Macular edema associated with uveitis	Supra- choroidal	Treatment response noted up to 9 months in 50% of patients	Active ocular infection, known hypersensitivity to triamcinolone acetonide	Resistance during injection due to not being in the correct anatomical space; injection site pain	IOP elevation >10 mmHg from baseline in 14.3%; lower rates of cataract compared with intravitreal options

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